GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | cis | rs4409766 | 1 | rs7098825 | chr10:104628234 | C10orf26 | chr10:104503727-104591851:+ | -0.21 | -3.64 | 0.000299 | Hypertension;Systolic blood pressure;Diastolic blood pressure |
| THCA | cis | rs4409766 | 1 | rs7098825 | chr10:104628234 | SFXN2 | chr10:104474298-104498946:+ | -0.34 | -4.06 | 5.64E-5 | Hypertension;Systolic blood pressure;Diastolic blood pressure |
| THCA | cis | rs1008953 | 1 | rs7099 | chr20:43997646 | ZNF335 | chr20:44577293-44600833:- | 0.14 | 3.4 | 0.000738 | Psoriasis |
| THCA | cis | rs778371 | 1 | rs709937 | chr2:233744021 | GIGYF2 | chr2:233562015-233725285:+ | 0.11 | 3.81 | 0.000158 | Schizophrenia |
| THCA | cis | rs778371 | 1 | rs709937 | chr2:233744021 | KCNJ13 | chr2:233630860-233641275:- | 0.13 | 3.48 | 0.000551 | Schizophrenia |
| THCA | cis | rs6479891 | 1 | rs7099425 | chr10:64960717 | LOC84989 | chr10:65224989-65226320:+ | -0.28 | -4.51 | 8.21E-6 | Arthritis (juvenile idiopathic) |
| THCA | cis | rs6479891 | 1 | rs7099425 | chr10:64960717 | NRBF2 | chr10:64893007-64914785:+ | -0.28 | -4.78 | 2.31E-6 | Arthritis (juvenile idiopathic) |
| THCA | cis | rs11190604 | 1 | rs7099913 | chr10:102314777 | SEC31B | chr10:102246403-102289636:- | -0.29 | -9.35 | 3.47E-19 | Palmitoleic acid (16:1n-7) plasma levels |
| THCA | cis | rs11190604 | 1 | rs7099965 | chr10:102301165 | SEC31B | chr10:102246403-102289636:- | -0.29 | -9.16 | 1.47E-18 | Palmitoleic acid (16:1n-7) plasma levels |
| THCA | cis | rs12780845 | 1 | rs7100163 | chr10:17181177 | TRDMT1 | chr10:17184983-17243681:- | -0.44 | -9.9 | 3.96E-21 | Homocysteine levels |
| THCA | cis | rs11190604 | 1 | rs7100386 | chr10:102301417 | SEC31B | chr10:102246403-102289636:- | -0.28 | -9.04 | 3.94E-18 | Palmitoleic acid (16:1n-7) plasma levels |
| THCA | cis | rs7069346 | 1 | rs7100697 | chr10:124745323 | C10orf88 | chr10:124690419-124713919:- | -0.22 | -4.08 | 5.37E-5 | Migraine without aura |
| THCA | cis | rs7107174 | 1 | rs7101429 | chr11:77992967 | NARS2 | chr11:78147017-78285909:- | -0.36 | -6.49 | 2.15E-10 | Testicular germ cell tumor |
| THCA | cis | rs7116495 | 1 | rs7101701 | chr11:71762155 | FAM86C | chr11:71498557-71512276:+ | 0.32 | 3.91 | 0.000107 | Severe influenza A (H1N1) infection |
| THCA | cis | rs10899021 | 1 | rs7102084 | chr11:74358132 | POLD3 | chr11:74303629-74353765:+ | -0.23 | -3.8 | 0.000162 | Response to metformin (IC50) |